Synthesis and Biological Evaluation of Termini-Modified and Cyclic Variants of the Connexin43 Inhibitor Peptide5

Peptide5 is a 12–amino acid mimetic peptide that corresponds to a region of the extracellular loop 2 (EL2) of connexin43. Peptide5 regulates both cellular communication with the cytoplasm (hemichannels) and cell-to-cell communication (gap junctions), and both processes are implicated in neurological...

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Detalles Bibliográficos
Autores principales: Crystal Chan, Sin Hang, Griffin, Jarred M., Clemett, Connor A., Brimble, Margaret A., O’Carroll, Simon J., Harris, Paul W. R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9513234/
https://www.ncbi.nlm.nih.gov/pubmed/36176893
http://dx.doi.org/10.3389/fchem.2022.877618

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9513234/
https://www.ncbi.nlm.nih.gov/pubmed/36176893
http://dx.doi.org/10.3389/fchem.2022.877618

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