Selective transduction of cerebellar Purkinje and granule neurons using delivery of AAV-PHP.eB and AAVrh10 vectors at axonal terminal locations

Adeno-associated virus (AAV)-based brain gene therapies require precision without off-targeting of unaffected neurons to avoid side effects. The cerebellum and its cell populations, including granule and Purkinje cells, are vulnerable to neurodegeneration; hence, conditions to deliver the therapy to...

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Detalles Bibliográficos
Autores principales: Surdyka, Magdalena, Jesion, Ewelina, Niewiadomska-Cimicka, Anna, Trottier, Yvon, Kalinowska-Pośka, Żaneta, Figiel, Maciej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Molecular Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9513253/
https://www.ncbi.nlm.nih.gov/pubmed/36176957
http://dx.doi.org/10.3389/fnmol.2022.947490

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9513253/
https://www.ncbi.nlm.nih.gov/pubmed/36176957
http://dx.doi.org/10.3389/fnmol.2022.947490

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