Hedgehog acyltransferase catalyzes a random sequential reaction and utilizes multiple fatty acyl-CoA substrates

Sonic hedgehog (Shh) signaling is a key component of embryonic development and is a driving force in several cancers. Hedgehog acyltransferase (Hhat), a member of the membrane-bound O-acyltransferase family of enzymes, catalyzes the attachment of palmitate to the N-terminal cysteine of Shh, a posttr...

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Detalles Bibliográficos
Autores principales: Schonbrun, Adina R., Resh, Marilyn D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9513256/
https://www.ncbi.nlm.nih.gov/pubmed/36030053
http://dx.doi.org/10.1016/j.jbc.2022.102422

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9513256/
https://www.ncbi.nlm.nih.gov/pubmed/36030053
http://dx.doi.org/10.1016/j.jbc.2022.102422

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