Prophylactic administration of miR-451 inhibitor decreases osteoarthritis severity in rats

Transfection of chondrocytes with microRNA-451(miR-451), present in growth zone cartilage of the growth plate, upregulates production of enzymes association with extracellular matrix degradation. miR-451 is also present in articular cartilage and exacerbates IL-1β effects in articular chondrocytes....

Descripción completa

Detalles Bibliográficos
Autores principales: Scott, Kayla M., Cohen, D. Joshua, Nielson, Dane W., Kim, Gloria, Olson, Lucas C., McClure, Michael J., Grinstaff, Mark W., Boyan, Barbara D., Schwartz, Zvi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9513290/
https://www.ncbi.nlm.nih.gov/pubmed/36167718
http://dx.doi.org/10.1038/s41598-022-20415-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9513290/
https://www.ncbi.nlm.nih.gov/pubmed/36167718
http://dx.doi.org/10.1038/s41598-022-20415-0

Ejemplares similares