Loss of the Fbw7 tumor suppressor rewires cholesterol metabolism in cancer cells leading to activation of the PI3K-AKT signalling axis

The sterol regulatory-element binding proteins (SREBPs) are transcription factors controlling cholesterol and fatty acid synthesis and metabolism. There are three SREBP proteins, SREBP1a, SREBP1c and SREBP2, with SREBP1a being the strongest transcription factor. The expression of SREBP1a is restrict...

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Detalles Bibliográficos
Autores principales: Bengoechea-Alonso, Maria T., Aldaalis, Arwa, Ericsson, Johan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9513553/
https://www.ncbi.nlm.nih.gov/pubmed/36176395
http://dx.doi.org/10.3389/fonc.2022.990672

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9513553/
https://www.ncbi.nlm.nih.gov/pubmed/36176395
http://dx.doi.org/10.3389/fonc.2022.990672

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