Sustained glucagon receptor antagonism in insulin-deficient high-fat-fed mice

Discerning modification to the amino acid sequence of native glucagon can generate specific glucagon receptor (GCGR) antagonists, that include desHis(1)Pro(4)Glu(9)-glucagon and the acylated form desHis(1)Pro(4)Glu(9)(Lys(12)PAL)-glucagon. In the current study, we have evaluated the metabolic benefi...

Descripción completa

Detalles Bibliográficos
Autores principales: Lafferty, Ryan A, McShane, Laura M, Franklin, Zara J, Flatt, Peter R, O’Harte, Finbarr P M, Irwin, Nigel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bioscientifica Ltd 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9513641/
https://www.ncbi.nlm.nih.gov/pubmed/36005280
http://dx.doi.org/10.1530/JOE-22-0106

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9513641/
https://www.ncbi.nlm.nih.gov/pubmed/36005280
http://dx.doi.org/10.1530/JOE-22-0106

Ejemplares similares