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Sustained glucagon receptor antagonism in insulin-deficient high-fat-fed mice

Discerning modification to the amino acid sequence of native glucagon can generate specific glucagon receptor (GCGR) antagonists, that include desHis(1)Pro(4)Glu(9)-glucagon and the acylated form desHis(1)Pro(4)Glu(9)(Lys(12)PAL)-glucagon. In the current study, we have evaluated the metabolic benefi...

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Detalles Bibliográficos
Autores principales:	Lafferty, Ryan A, McShane, Laura M, Franklin, Zara J, Flatt, Peter R, O’Harte, Finbarr P M, Irwin, Nigel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Bioscientifica Ltd 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9513641/ https://www.ncbi.nlm.nih.gov/pubmed/36005280 http://dx.doi.org/10.1530/JOE-22-0106

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