Novel thiazole derivatives incorporating phenyl sulphonyl moiety as potent BRAFV600E kinase inhibitors targeting melanoma

Novel thiazole derivatives possessing phenyl sulfonyl moiety were designed and synthesized as B-RAFV600E kinase inhibitors based on the clinically-approved anticancer drug, dabrafenib. All target compounds showed significant inhibition of B-RAFV600E kinase enzyme at nanomolar levels. Compounds 7b an...

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Detalles Bibliográficos
Autores principales: Khormi, Afaf Y., Farghaly, Thoraya. A., Bayazeed, Abrar, Al-Ghamdi, Youssef O., Abdulwahab, Hanan Gaber, Shaaban, Mohamed R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9513682/
https://www.ncbi.nlm.nih.gov/pubmed/36276003
http://dx.doi.org/10.1039/d2ra03624j

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9513682/
https://www.ncbi.nlm.nih.gov/pubmed/36276003
http://dx.doi.org/10.1039/d2ra03624j

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