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Ultrastructural characterization of dark microglia during aging in a mouse model of Alzheimer’s disease pathology and in human post-mortem brain samples

A diverse heterogeneity of microglial cells was previously described in Alzheimer’s disease (AD) pathology, including dark microglia, a state characterized by ultrastructural markers of cellular stress. To provide novel insights into the roles of dark microglia during aging in the context of AD path...

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Detalles Bibliográficos
Autores principales: St-Pierre, Marie-Kim, Carrier, Micaël, González Ibáñez, Fernando, Šimončičová, Eva, Wallman, Marie-Josée, Vallières, Luc, Parent, Martin, Tremblay, Marie-Ève
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9513936/
https://www.ncbi.nlm.nih.gov/pubmed/36167544
http://dx.doi.org/10.1186/s12974-022-02595-8