Haptoglobin treatment contributes to regulating nitric oxide signal and reduces oxidative stress in the penis: A preventive treatment for priapism in sickle cell disease

Background: In sickle cell disease (SCD), reduced bioavailability of endothelial NO and cGMP results in reduced expression of phosphodiesterase type 5 (PDE5), thus impairing the penile erection control mechanism and resulting in prolonged penile erection (priapism). In SCD, reduced NO bioavailabilit...

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Detalles Bibliográficos
Autores principales: Pereira, Pamela da Silva, Pereira, Dalila Andrade, Calmasini, Fabiano Beraldi, Reis, Leonardo O., Brinkman, Nathan, Burnett, Arthur L., Costa, Fernando Ferreira, Silva, Fábio Henrique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9514379/
https://www.ncbi.nlm.nih.gov/pubmed/36176769
http://dx.doi.org/10.3389/fphys.2022.961534

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9514379/
https://www.ncbi.nlm.nih.gov/pubmed/36176769
http://dx.doi.org/10.3389/fphys.2022.961534

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