Role of GABA(A) receptor depolarization-mediated VGCC activation in sevoflurane-induced cognitive impairment in neonatal mice

BACKGROUND: In neonatal mice, anesthesia with sevoflurane depolarizes the GABA Type A receptor (GABA(A)R), which leads to cognitive impairment. Calcium accumulation in neurons can lead to neurotoxicity. Voltage-gated calcium channels (VGCCs) can increase intracellular calcium concentration under iso...

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Detalles Bibliográficos
Autores principales: Zeng, Shuang, Zhu, Ruilou, Wang, Yangyang, Yang, Yitian, Li, Ningning, Fu, Ningning, Sun, Mingyang, Zhang, Jiaqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cellular Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9514857/
https://www.ncbi.nlm.nih.gov/pubmed/36176629
http://dx.doi.org/10.3389/fncel.2022.964227

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9514857/
https://www.ncbi.nlm.nih.gov/pubmed/36176629
http://dx.doi.org/10.3389/fncel.2022.964227

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