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Role of GABA(A) receptor depolarization-mediated VGCC activation in sevoflurane-induced cognitive impairment in neonatal mice
BACKGROUND: In neonatal mice, anesthesia with sevoflurane depolarizes the GABA Type A receptor (GABA(A)R), which leads to cognitive impairment. Calcium accumulation in neurons can lead to neurotoxicity. Voltage-gated calcium channels (VGCCs) can increase intracellular calcium concentration under iso...
Autores principales: | Zeng, Shuang, Zhu, Ruilou, Wang, Yangyang, Yang, Yitian, Li, Ningning, Fu, Ningning, Sun, Mingyang, Zhang, Jiaqiang |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9514857/ https://www.ncbi.nlm.nih.gov/pubmed/36176629 http://dx.doi.org/10.3389/fncel.2022.964227 |
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