Radiotherapy-induced oxidative stress and fibrosis in breast cancer are suppressed by vactosertib, a novel, orally bioavailable TGF-β/ALK5 inhibitor

Radio-resistance resulting from radiotherapy-induced fibrosis is a major clinical obstacle in breast cancer treatment because it typically leads to cancer recurrence, treatment failure, and patient death. Transforming growth factor-β (TGF-β) is a key signal messenger in fibrosis, which plays an impo...

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Detalles Bibliográficos
Autores principales: Park, Jiyoung, Choi, Jiwon, Cho, Ilyoung, Sheen, Yhun Yhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9515166/
https://www.ncbi.nlm.nih.gov/pubmed/36167880
http://dx.doi.org/10.1038/s41598-022-20050-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9515166/
https://www.ncbi.nlm.nih.gov/pubmed/36167880
http://dx.doi.org/10.1038/s41598-022-20050-9

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