A protein-based cGAS-STING nanoagonist enhances T cell-mediated anti-tumor immune responses

cGAS-STING pathway is a key DNA-sensing machinery and emerges as a promising target to overcome the immunoresistance of solid tumors. Here we describe a bovine serum albumin (BSA)/ferritin-based nanoagonist incorporating manganese (II) ions and β-lapachone, which cooperatively activates cGAS-STING s...

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Detalles Bibliográficos
Autores principales: Wang, Xuan, Liu, Yingqi, Xue, Chencheng, Hu, Yan, Zhao, Yuanyuan, Cai, Kaiyong, Li, Menghuan, Luo, Zhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9515186/
https://www.ncbi.nlm.nih.gov/pubmed/36167857
http://dx.doi.org/10.1038/s41467-022-33301-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9515186/
https://www.ncbi.nlm.nih.gov/pubmed/36167857
http://dx.doi.org/10.1038/s41467-022-33301-0

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