Bis-pharmacophore of cinnamaldehyde-clubbed thiosemicarbazones as potent carbonic anhydrase-II inhibitors

Here, we report the synthesis, carbonic anhydrase-II (CA-II) inhibition and structure–activity relationship studies of cinnamaldehyde-clubbed thiosemicarbazones derivatives. The derivatives showed potent activities in the range of 10.3 ± 0.62–46.6 ± 0.62 µM. Among all the synthesized derivatives, co...

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Detalles Bibliográficos
Autores principales: Rasool, Asif, Batool, Zahra, Khan, Majid, Halim, Sobia Ahsan, Shafiq, Zahid, Temirak, Ahmed, Salem, Mohamed A., Ali, Tarik E., Khan, Ajmal, Al-Harrasi, Ahmed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9515202/
https://www.ncbi.nlm.nih.gov/pubmed/36167735
http://dx.doi.org/10.1038/s41598-022-19975-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9515202/
https://www.ncbi.nlm.nih.gov/pubmed/36167735
http://dx.doi.org/10.1038/s41598-022-19975-y

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