Inhibiting ALK-TOPK signaling pathway promotes cell apoptosis of ALK-positive NSCLC

T-LAK cell-oriented protein kinase (TOPK) is a potential therapeutic target in tumors. However, its role in anaplastic lymphoma kinase (ALK)-positive non-small cell lung cancer (NSCLC) has not been reported. Here, we found that TOPK was highly expressed in ALK-positive NSCLC. Additionally, ALK was i...

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Detalles Bibliográficos
Autores principales: Xiao, Juanjuan, Zhang, Lu, Yi, Huijun, Zou, Ling, Mo, Jianmei, Xue, Feng, Zheng, Jinhua, Huang, Yingze, Lu, Hui, Wu, Hansheng, Xue, Peipei, Zhang, Xin, He, Lifei, Li, Zhaoxin, Pang, Shigui, Qiao, Guibin, Duan, Qiuhong, Zhu, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9515217/
https://www.ncbi.nlm.nih.gov/pubmed/36167821
http://dx.doi.org/10.1038/s41419-022-05260-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9515217/
https://www.ncbi.nlm.nih.gov/pubmed/36167821
http://dx.doi.org/10.1038/s41419-022-05260-3

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