Non-apoptotic activity of the mitochondrial protein SMAC/Diablo in lung cancer: Novel target to disrupt survival, inflammation, and immunosuppression

Mitochondrial SMAC/Diablo induces apoptosis by binding the inhibitor of apoptosis proteins (IAPs), thereby activating caspases and, subsequently, apoptosis. Previously, we found that despite its pro-apoptotic activity, SMAC/Diablo is overexpressed in cancer, and demonstrated that in cancer it posses...

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Detalles Bibliográficos
Autores principales: Pandey, Swaroop Kumar, Shteinfer-Kuzmine, Anna, Chalifa-Caspi, Vered, Shoshan-Barmatz, Varda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9515501/
https://www.ncbi.nlm.nih.gov/pubmed/36185255
http://dx.doi.org/10.3389/fonc.2022.992260

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9515501/
https://www.ncbi.nlm.nih.gov/pubmed/36185255
http://dx.doi.org/10.3389/fonc.2022.992260

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