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Non-apoptotic activity of the mitochondrial protein SMAC/Diablo in lung cancer: Novel target to disrupt survival, inflammation, and immunosuppression

Mitochondrial SMAC/Diablo induces apoptosis by binding the inhibitor of apoptosis proteins (IAPs), thereby activating caspases and, subsequently, apoptosis. Previously, we found that despite its pro-apoptotic activity, SMAC/Diablo is overexpressed in cancer, and demonstrated that in cancer it posses...

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Detalles Bibliográficos
Autores principales:	Pandey, Swaroop Kumar, Shteinfer-Kuzmine, Anna, Chalifa-Caspi, Vered, Shoshan-Barmatz, Varda
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9515501/ https://www.ncbi.nlm.nih.gov/pubmed/36185255 http://dx.doi.org/10.3389/fonc.2022.992260

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