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Combinatorial suicide gene strategies for the safety of cell therapies
Gene-modified cellular therapies carry inherent risks of severe and potentially fatal adverse events, including the expansion of alloreactive cells or malignant transformation due to insertional mutagenesis. Strategies to mitigate uncontrolled proliferation of gene-modified cells include co-transfec...
Autores principales: | Falcon, Corey, Smith, Lauren, Al-Obaidi, Mustafa, Abu Zaanona, Mohammed, Purvis, Katelyn, Minagawa, Kentaro, Athar, Mohammad, Salzman, Donna, Bhatia, Ravi, Goldman, Frederick, Di Stasi, Antonio |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9515659/ https://www.ncbi.nlm.nih.gov/pubmed/36189285 http://dx.doi.org/10.3389/fimmu.2022.975233 |
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