Prenatal methotrexate injection increases behaviors possibly associated with depression and/or autism in rat offspring; A new animal model for mental disorder, based on folate metabolism deficit during pregnancy

BACKGROUND: Deficiency of folate, an essential vitamin for DNA synthesis and methylation, is reported as a risk factor for mental disorders. Considering a possibility that folate metabolism deficit during pregnancy may disturb CNS development and increase mental disorders in offspring, we treated pr...

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Detalles Bibliográficos
Autores principales: Amada, Naoki, Kakumoto, Yusuke, Futamura, Takashi, Maeda, Kenji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9515720/
https://www.ncbi.nlm.nih.gov/pubmed/35502620
http://dx.doi.org/10.1002/npr2.12255

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9515720/
https://www.ncbi.nlm.nih.gov/pubmed/35502620
http://dx.doi.org/10.1002/npr2.12255

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