Integrated TCR repertoire analysis and single-cell transcriptomic profiling of tumor-infiltrating T cells in renal cell carcinoma identifies shared and tumor-restricted expanded clones with unique phenotypes

Objective responses of metastatic renal cell carcinoma (RCC) associated with systemic immunotherapies suggest the potential for T-cell-mediated tumor clearance. Recent analyses associate clonally expanded T cells present in the tumor at diagnosis with responses to immune checkpoint inhibitors (ICIs)...

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Detalles Bibliográficos
Autores principales: Xu, Yuexin, Morales, Alicia J., Towlerton, Andrea M. H., Akilesh, Shreeram, Miller, Chris P., Tykodi, Scott S., Warren, Edus H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9515957/
https://www.ncbi.nlm.nih.gov/pubmed/36185254
http://dx.doi.org/10.3389/fonc.2022.952252

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9515957/
https://www.ncbi.nlm.nih.gov/pubmed/36185254
http://dx.doi.org/10.3389/fonc.2022.952252

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