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Integrated TCR repertoire analysis and single-cell transcriptomic profiling of tumor-infiltrating T cells in renal cell carcinoma identifies shared and tumor-restricted expanded clones with unique phenotypes

Objective responses of metastatic renal cell carcinoma (RCC) associated with systemic immunotherapies suggest the potential for T-cell-mediated tumor clearance. Recent analyses associate clonally expanded T cells present in the tumor at diagnosis with responses to immune checkpoint inhibitors (ICIs)...

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Detalles Bibliográficos
Autores principales:	Xu, Yuexin, Morales, Alicia J., Towlerton, Andrea M. H., Akilesh, Shreeram, Miller, Chris P., Tykodi, Scott S., Warren, Edus H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9515957/ https://www.ncbi.nlm.nih.gov/pubmed/36185254 http://dx.doi.org/10.3389/fonc.2022.952252

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