Unraveling key interactions and the mechanism of demethylation during hAGT-mediated DNA repair via simulations

Alkylating agents pose the biggest threat to the genomic integrity of cells by damaging DNA bases through regular alkylation. Such damages are repaired by several automated types of machinery inside the cell. O6-alkylguanine-DNA alkyltransferase (AGT) is an enzyme that performs the direct repair of...

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Detalles Bibliográficos
Autores principales: T. G., Shruti, Siddiqui, Shakir Ali, Dubey, Kshatresh Dutta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9515978/
https://www.ncbi.nlm.nih.gov/pubmed/36188219
http://dx.doi.org/10.3389/fmolb.2022.975046

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9515978/
https://www.ncbi.nlm.nih.gov/pubmed/36188219
http://dx.doi.org/10.3389/fmolb.2022.975046

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