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Unraveling key interactions and the mechanism of demethylation during hAGT-mediated DNA repair via simulations
Alkylating agents pose the biggest threat to the genomic integrity of cells by damaging DNA bases through regular alkylation. Such damages are repaired by several automated types of machinery inside the cell. O6-alkylguanine-DNA alkyltransferase (AGT) is an enzyme that performs the direct repair of...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9515978/ https://www.ncbi.nlm.nih.gov/pubmed/36188219 http://dx.doi.org/10.3389/fmolb.2022.975046 |