Novel formulation of c-di-GMP with cytidinyl/cationic lipid reverses T cell exhaustion and activates stronger anti-tumor immunity

Rationale: Cyclic dinucleotides (cDNs) are a promising class of immunotherapeutic agent targeting stimulator of interferon genes (STING). However, enzymatic instability and transmembrane barriers limit the extensive clinical application of cDNs. Thus, a novel delivery system, composed of a neutral c...

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Detalles Bibliográficos
Autores principales: Yu, Xiaotong, Yu, Jing, Dai, Hong, Deng, Chenyun, Sun, Xudong, Long, Sijie, Jiang, Zhujun, Jin, Hongyan, Guan, Zhu, Yang, Zhenjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9516232/
https://www.ncbi.nlm.nih.gov/pubmed/36185614
http://dx.doi.org/10.7150/thno.71010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9516232/
https://www.ncbi.nlm.nih.gov/pubmed/36185614
http://dx.doi.org/10.7150/thno.71010

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