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Novel formulation of c-di-GMP with cytidinyl/cationic lipid reverses T cell exhaustion and activates stronger anti-tumor immunity
Rationale: Cyclic dinucleotides (cDNs) are a promising class of immunotherapeutic agent targeting stimulator of interferon genes (STING). However, enzymatic instability and transmembrane barriers limit the extensive clinical application of cDNs. Thus, a novel delivery system, composed of a neutral c...
Autores principales: | Yu, Xiaotong, Yu, Jing, Dai, Hong, Deng, Chenyun, Sun, Xudong, Long, Sijie, Jiang, Zhujun, Jin, Hongyan, Guan, Zhu, Yang, Zhenjun |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ivyspring International Publisher
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9516232/ https://www.ncbi.nlm.nih.gov/pubmed/36185614 http://dx.doi.org/10.7150/thno.71010 |
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