Dual-targeted magnetic mesoporous silica nanoparticles reduce brain amyloid-β burden via depolymerization and intestinal metabolism

Rationale: Active removal of excess peripheral amyloid-β (Aβ) can potentially treat Alzheimer's disease (AD). However, the peripheral clearance of Aβ using an anti-Aβ monoclonal antibody (mAb) cannot remove PET-detectable Aβ within the brain. This may be due to the inability of mAb to cross the...

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Detalles Bibliográficos
Autores principales: Liu, Ni, Liang, Xiaohan, Yang, Changwen, Hu, Shun, Luo, Qingming, Luo, Haiming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9516238/
https://www.ncbi.nlm.nih.gov/pubmed/36185606
http://dx.doi.org/10.7150/thno.76574

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9516238/
https://www.ncbi.nlm.nih.gov/pubmed/36185606
http://dx.doi.org/10.7150/thno.76574

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