Design of stapled peptide-based PROTACs for MDM2/MDMX atypical degradation and tumor suppression

Rationale: Although stapled peptides offer a powerful solution to overcome the susceptibility of linear peptides to proteolytic degradation and improve their ability to cross membranes, an efficient and durable disease treatment strategy has not yet been developed due to the inevitable elimination o...

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Detalles Bibliográficos
Autores principales: Chen, Si, Li, Xiang, Li, Yinghua, Yuan, Xing, Geng, Chenchen, Gao, Songyan, Li, Jinyang, Ma, Bohan, Wang, Zhe, Lu, Wuyuan, Hu, Hong-Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9516243/
https://www.ncbi.nlm.nih.gov/pubmed/36185610
http://dx.doi.org/10.7150/thno.75444

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9516243/
https://www.ncbi.nlm.nih.gov/pubmed/36185610
http://dx.doi.org/10.7150/thno.75444

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