Development of GPC2-directed chimeric antigen receptors using mRNA for pediatric brain tumors

BACKGROUND: Pediatric brain tumors are the leading cause of cancer death in children with an urgent need for innovative therapies. Glypican 2 (GPC2) is a cell surface oncoprotein expressed in neuroblastoma for which targeted immunotherapies have been developed. This work aimed to characterize GPC2 e...

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Detalles Bibliográficos
Autores principales: Foster, Jessica B, Griffin, Crystal, Rokita, Jo Lynne, Stern, Allison, Brimley, Cameron, Rathi, Komal, Lane, Maria V, Buongervino, Samantha N, Smith, Tiffany, Madsen, Peter J, Martinez, Daniel, Delaidelli, Alberto, Sorensen, Poul H, Wechsler-Reya, Robert J, Karikó, Katalin, Storm, Phillip B, Barrett, David M, Resnick, Adam C, Maris, John M, Bosse, Kristopher R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Immune Cell Therapies and Immune Cell Engineering
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9516314/
https://www.ncbi.nlm.nih.gov/pubmed/36167467
http://dx.doi.org/10.1136/jitc-2021-004450

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9516314/
https://www.ncbi.nlm.nih.gov/pubmed/36167467
http://dx.doi.org/10.1136/jitc-2021-004450

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