Isothermal titration calorimetry determination of thermodynamics of binding of cocaine and its metabolites to humanized h2E2 anti-cocaine mAb

We analyzed the thermodynamics of binding of cocaine and several cocaine metabolites to a humanized anti-cocaine mAb (h2E2), which is under development for the treatment of cocaine use disorders, using isothermal titration calorimetry. The calculated equilibrium dissociation (binding) constants were...

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Detalles Bibliográficos
Autores principales: Kirley, Terence L., Norman, Andrew B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9516381/
https://www.ncbi.nlm.nih.gov/pubmed/36186732
http://dx.doi.org/10.1016/j.bbrep.2022.101354

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9516381/
https://www.ncbi.nlm.nih.gov/pubmed/36186732
http://dx.doi.org/10.1016/j.bbrep.2022.101354

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