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Microarchitectural mimicking of stroma-induced vasculature compression in pancreatic tumors using a 3D engineered model
Fibrotic tumors, such as pancreatic ductal adenocarcinoma (PDAC), are characterized for high desmoplastic reaction, which results in high intra-tumoral solid stress leading to the compression of blood vessels. These microarchitectural alterations cause loss of blood flow and poor intra-tumoral deliv...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
KeAi Publishing
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9516389/ https://www.ncbi.nlm.nih.gov/pubmed/36203956 http://dx.doi.org/10.1016/j.bioactmat.2022.09.015 |