Cargando…
Design, synthesis and evaluation of novel small molecules acting as Keap1-Nrf2 protein-protein interaction inhibitors
Direct interference with Kelch-like ECH-associated protein 1 (Keap1)-Nrf2 protein-protein interaction (PPI) has recently been introduced as an attractive approach to control life-threatening diseases like myocarditis. The present study aimed to investigate the potential application in myocarditis of...
Autores principales: | Sun, Yunfeng, Zheng, Lulu, Yang, Bo, Ge, Shuyu, Li, Qiang, Zhang, Mingwan, Shen, Shenghui, Ying, Yin |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9518255/ https://www.ncbi.nlm.nih.gov/pubmed/36128875 http://dx.doi.org/10.1080/14756366.2022.2124408 |
Ejemplares similares
-
Discovery of Keap1−Nrf2 small−molecule inhibitors from phytochemicals based on molecular docking
por: Li, Maiquan, et al.
Publicado: (2019) -
KEAP1‐NRF2 protein–protein interaction inhibitors: Design, pharmacological properties and therapeutic potential
por: Crisman, Enrique, et al.
Publicado: (2022) -
Identification of novel indole derivatives acting as inhibitors of the Keap1–Nrf2 interaction
por: Cosimelli, Barbara, et al.
Publicado: (2019) -
Emerging Screening Approaches in the Development of Nrf2–Keap1 Protein–Protein Interaction Inhibitors
por: Leung, Chung-Hang, et al.
Publicado: (2019) -
Identification of a novel small-molecule Keap1–Nrf2 PPI inhibitor with cytoprotective effects on LPS-induced cardiomyopathy
por: Jiang, Cheng-Shi, et al.
Publicado: (2018)