Design and synthesis of benzothiazole-based SLC-0111 analogues as new inhibitors for the cancer-associated carbonic anhydrase isoforms IX and XII

In this work, different series of benzothiazole-based sulphonamides 8a-c, 10, 12, 16a-b and carboxylic acids 14a-c were developed as novel SLC-0111 analogues with the goal of generating potent carbonic anhydrase (CA) inhibitors. The adopted strategy involved replacing the 4-fluorophenyl tail in SLC-...

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Detalles Bibliográficos
Autores principales: Al-Warhi, Tarfah, Elbadawi, Mostafa M., Bonardi, Alessandro, Nocentini, Alessio, Al-Karmalawy, Ahmed A., Aljaeed, Nada, Alotaibi, Ohoud J., Abdel-Aziz, Hatem A., Supuran, Claudiu T., Eldehna, Wagdy M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9518259/
https://www.ncbi.nlm.nih.gov/pubmed/36146927
http://dx.doi.org/10.1080/14756366.2022.2124409

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9518259/
https://www.ncbi.nlm.nih.gov/pubmed/36146927
http://dx.doi.org/10.1080/14756366.2022.2124409

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