Design and synthesis of novel quinazolinone-based derivatives as EGFR inhibitors with antitumor activity

Nineteen new quinazolin-4(3H)-one derivatives 3a–g and 6a–l were designed and synthesised to inhibit EGFR. The antiproliferative activity of the synthesised compounds was tested in vitro against 60 different human cell lines. The most potent compound 6d displayed superior sub-micromolar antiprolifer...

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Detalles Bibliográficos
Autores principales: Sonousi, Amr, Hassan, Rasha A., Osman, Eman O., Abdou, Amr M., Emam, Soha H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9518264/
https://www.ncbi.nlm.nih.gov/pubmed/36146940
http://dx.doi.org/10.1080/14756366.2022.2118735

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9518264/
https://www.ncbi.nlm.nih.gov/pubmed/36146940
http://dx.doi.org/10.1080/14756366.2022.2118735

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