Privileged multi-target directed propargyl-tacrines combining cholinesterase and monoamine oxidase inhibition activities

Twenty-four novel compounds bearing tetrahydroacridine and N-propargyl moieties have been designed, synthesised, and evaluated in vitro for their anti-cholinesterase and anti-monoamine oxidase activities. Propargyltacrine 23 (IC(50) = 21 nM) was the most potent acetylcholinesterase (AChE) inhibitor,...

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Detalles Bibliográficos
Autores principales: Chrienova, Zofia, Nepovimova, Eugenie, Andrys, Rudolf, Dolezal, Rafael, Janockova, Jana, Muckova, Lubica, Fabova, Lenka, Soukup, Ondrej, Oleksak, Patrik, Valis, Martin, Korabecny, Jan, Marco-Contelles, José, Kuca, Kamil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9518283/
https://www.ncbi.nlm.nih.gov/pubmed/36131624
http://dx.doi.org/10.1080/14756366.2022.2122054

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9518283/
https://www.ncbi.nlm.nih.gov/pubmed/36131624
http://dx.doi.org/10.1080/14756366.2022.2122054

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