Complementary CRISPR genome-wide genetic screens in PARP10-knockout and overexpressing cells identify synthetic interactions for PARP10-mediated cellular survival

PARP10 is a mono-ADP-ribosyltransferase with multiple cellular functions, including proliferation, apoptosis, metabolism and DNA repair. PARP10 is overexpressed in a significant proportion of tumors, particularly breast and ovarian cancers. Identifying genetic susceptibilities based on PARP10 expres...

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Detalles Bibliográficos
Autores principales: Khatib, Jude B., Schleicher, Emily M., Jackson, Lindsey M., Dhoonmoon, Ashna, Moldovan, George-Lucian, Nicolae, Claudia M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9518689/
https://www.ncbi.nlm.nih.gov/pubmed/36187556
http://dx.doi.org/10.18632/oncotarget.28277

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9518689/
https://www.ncbi.nlm.nih.gov/pubmed/36187556
http://dx.doi.org/10.18632/oncotarget.28277

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