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Optogenetic stimulation of dynorphinergic neurons within the dorsal raphe activate kappa opioid receptors in the ventral tegmental area and ablation of dorsal raphe prodynorphin or kappa receptors in dopamine neurons blocks stress potentiation of cocaine reward

Behavioral stress exposure increases the risk of drug-taking in individuals with substance use disorders by mechanisms involving the dynorphins, which are the endogenous neuropeptides for the kappa opioid receptor (KOR). KOR agonists have been shown to encode dysphoria, aversion, and changes in rewa...

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Detalles Bibliográficos
Autores principales: Abraham, Antony D., Casello, Sanne M., Land, Benjamin B., Chavkin, Charles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9518814/
https://www.ncbi.nlm.nih.gov/pubmed/36176476
http://dx.doi.org/10.1016/j.addicn.2022.100005