Physicochemical and biological impact of metal-catalyzed oxidation of IgG1 monoclonal antibodies and antibody-drug conjugates via reactive oxygen species

Biotherapeutics are exposed to common transition metal ions such as Cu(II) and Fe(II) during manufacturing processes and storage. IgG1 biotherapeutics are vulnerable to reactive oxygen species (ROS) generated via the metal-catalyzed oxidation reactions. Exposure to these metal ions can lead to poten...

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Detalles Bibliográficos
Autores principales: Glover, Zephania Kwong, Wecksler, Aaron, Aryal, Baikuntha, Mehta, Shrenik, Pegues, Melissa, Chan, Wayman, Lehtimaki, Mari, Luo, Allen, Sreedhara, Alavattam, Rao, V. Ashutosh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9519010/
https://www.ncbi.nlm.nih.gov/pubmed/36151884
http://dx.doi.org/10.1080/19420862.2022.2122957

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9519010/
https://www.ncbi.nlm.nih.gov/pubmed/36151884
http://dx.doi.org/10.1080/19420862.2022.2122957

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