Cargando…

Physicochemical and biological impact of metal-catalyzed oxidation of IgG1 monoclonal antibodies and antibody-drug conjugates via reactive oxygen species

Biotherapeutics are exposed to common transition metal ions such as Cu(II) and Fe(II) during manufacturing processes and storage. IgG1 biotherapeutics are vulnerable to reactive oxygen species (ROS) generated via the metal-catalyzed oxidation reactions. Exposure to these metal ions can lead to poten...

Descripción completa

Detalles Bibliográficos
Autores principales:	Glover, Zephania Kwong, Wecksler, Aaron, Aryal, Baikuntha, Mehta, Shrenik, Pegues, Melissa, Chan, Wayman, Lehtimaki, Mari, Luo, Allen, Sreedhara, Alavattam, Rao, V. Ashutosh
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2022
Materias:	Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9519010/ https://www.ncbi.nlm.nih.gov/pubmed/36151884 http://dx.doi.org/10.1080/19420862.2022.2122957

Ejemplares similares

Insights into ultra-low affinity lipase-antibody noncovalent complex binding mechanisms
por: Hecht, Elizabeth Sara, et al.
Publicado: (2022)

Impact of IgG subclass on monoclonal antibody developability
por: Cain, Paul, et al.
Publicado: (2023)

A comparative study on the physicochemical and biological stability of IgG(1) and monoclonal antibodies during spray drying process
por: Ramezani, Vahid, et al.
Publicado: (2014)

Impact of IgG subclass on molecular properties of monoclonal antibodies
por: Tang, Yu, et al.
Publicado: (2021)

Monoclonal Antibodies and Antibody Drug Conjugates in Multiple Myeloma
por: Radocha, Jakub, et al.
Publicado: (2021)

Antibody–receptor interactions mediate antibody-dependent cellular cytotoxicity
por: Sun, Yue, et al.
Publicado: (2021)

Deficiency in Cardiolipin Reduces Doxorubicin-Induced Oxidative Stress and Mitochondrial Damage in Human B-Lymphocytes
por: Aryal, Baikuntha, et al.
Publicado: (2016)

Specific protein carbonylation in human breast cancer tissue compared to adjacent healthy epithelial tissue
por: Aryal, Baikuntha, et al.
Publicado: (2018)

Human monoclonal antibodies and monoclonal antibody multispecificity.
por: Campbell, A. M., et al.
Publicado: (1987)

Distinct functions of monoclonal IgG antibody depend on antigen-site specificities
Publicado: (1979)

MONOCLONAL PRODUCTION OF BOTH IgM AND IgG1 ANTIHAPTEN ANTIBODY
por: Press, Joan L., et al.
Publicado: (1973)

Purification and characterization of monoclonal IgG antibodies recognizing Ebola virus glycoprotein
por: Han, Baek-Sang, et al.
Publicado: (2018)

YEAST SURFACE DISPLAY OF FULL-LENGTH IGG FOR ENGINEERING MONOCLONAL AND BISPECIFIC ANTIBODIES
por: Jiang, Youwei
Publicado: (2023)

Current and emerging monoclonal antibodies, antibody-drug conjugates, and bispecific antibodies in treatment of lymphoma
por: Atallah-Yunes, Suheil Albert, et al.
Publicado: (2022)

Washing with alkaline solutions in protein A purification improves physicochemical properties of monoclonal antibodies
por: Imura, Yuichi, et al.
Publicado: (2021)

Multiple organ-reactive IgG antibody induced by an antiidiotypic antibody to a human monoclonal IgM autoantibody
Publicado: (1986)

Production and Characterization of Mouse Monoclonal Antibodies Recognizing Multiple Subclasses of Human IgG
por: Hajighasemi, Fatemeh, et al.
Publicado: (2010)

Inhibition of invasive salmonella by orally administered IgA and IgG monoclonal antibodies
por: Richards, Angelene F., et al.
Publicado: (2020)

Epitope mapping of anti-drug antibodies to a clinical candidate bispecific antibody
por: Schick, Arthur J., et al.
Publicado: (2022)

Monoclonal antibody targeting the β-barrel assembly machine of Escherichia coli is bactericidal
por: Storek, Kelly M., et al.
Publicado: (2018)

Generation and Characterization of Mouse Hybridomas Secreting Monoclonal Antibodies Specific for Human IgG3
por: Hajighasemi, Fatemeh, et al.
Publicado: (2009)

Human-IgG-Neutralizing Monoclonal Antibodies Block the SARS-CoV-2 Infection
por: Wan, Jinkai, et al.
Publicado: (2020)

Effect of Fatty Acid Composition in Polysorbate 80 on the Stability of Therapeutic Protein Formulations
por: Pegues, Melissa A., et al.
Publicado: (2021)

The role of IgG subclass of mouse monoclonal antibodies in antibody-dependent enhancement of feline infectious peritonitis virus infection of feline macrophages
por: Hohdatsu, T., et al.
Publicado: (1994)

Monoclonal Antibodies in Cancer
por: Ghosh, A.K.
Publicado: (1986)

Pharmacokinetics of Monoclonal Antibodies
por: Ryman, Josiah T., et al.
Publicado: (2017)

Microbials for the production of monoclonal antibodies and antibody fragments
por: Spadiut, Oliver, et al.
Publicado: (2014)

Publisher Correction: Washing with alkaline solutions in protein A purification improves physicochemical properties of monoclonal antibodies
por: Imura, Yuichi, et al.
Publicado: (2021)

Selection of monoclonal antibody E48 IgG or U36 IgG for adjuvant radioimmunotherapy in head and neck cancer patients.
por: de Bree, R., et al.
Publicado: (1997)

The development and characterisation of porphyrin isothiocyanate–monoclonal antibody conjugates for photoimmunotherapy
por: Hudson, R, et al.
Publicado: (2005)

Selective Deactivation of Serum IgG: A General Strategy for the Enhancement of Monoclonal Antibody Receptor Interactions
por: Baruah, Kavitha, et al.
Publicado: (2012)

Treating cat allergy with monoclonal IgG antibodies that bind allergen and prevent IgE engagement
por: Orengo, J. M., et al.
Publicado: (2018)

Circulating Monoclonal IgG1-kappa Antibodies Causing Anti-glomerular Basement Membrane Nephritis
por: Vankalakunti, M., et al.
Publicado: (2017)

A toolbox of IgG subclass-switched recombinant monoclonal antibodies for enhanced multiplex immunolabeling of brain
por: Andrews, Nicolas P, et al.
Publicado: (2019)

Atg7- and Keap1-dependent autophagy protects breast cancer cell lines against mitoquinone-induced oxidative stress
por: Gonzalez, Yanira, et al.
Publicado: (2014)

Functional relevance of in vivo half antibody exchange of an IgG4 therapeutic antibody-drug conjugate
por: Herbener, Peter, et al.
Publicado: (2018)

From rabbit antibody repertoires to rabbit monoclonal antibodies
por: Weber, Justus, et al.
Publicado: (2017)

Her-2 Targeted Therapy in Advanced Urothelial Cancer: From Monoclonal Antibodies to Antibody-Drug Conjugates
por: Albarrán, Víctor, et al.
Publicado: (2022)

Monoclonal Antibodies to the Thyrotropin Receptor
por: Ando, Takao, et al.
Publicado: (2005)

Monoclonal antibodies for imaging and therapy.
por: Epenetos, A. A., et al.
Publicado: (1989)

Cannot write session to /tmp/vufind_sessions/sess_t65ve2eu1v0jtiq9lea88qjjdj