Therapeutic implications of mitochondrial stress–induced proteasome inhibitor resistance in multiple myeloma

The connections between metabolic state and therapy resistance in multiple myeloma (MM) are poorly understood. We previously reported that electron transport chain (ETC) suppression promotes sensitivity to the BCL-2 antagonist venetoclax. Here, we show that ETC suppression promotes resistance to pro...

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Detalles Bibliográficos
Autores principales: Sharma, Aditi, Nair, Remya, Achreja, Abhinav, Mittal, Anjali, Gupta, Pulkit, Balakrishnan, Kamakshi, Edgar, Claudia L., Animasahun, Olamide, Dwivedi, Bhakti, Barwick, Benjamin G., Gupta, Vikas A., Matulis, Shannon M., Bhasin, Manoj, Lonial, Sagar, Nooka, Ajay K., Wiita, Arun P., Boise, Lawrence H., Nagrath, Deepak, Shanmugam, Mala
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9519052/
https://www.ncbi.nlm.nih.gov/pubmed/36170375
http://dx.doi.org/10.1126/sciadv.abq5575

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9519052/
https://www.ncbi.nlm.nih.gov/pubmed/36170375
http://dx.doi.org/10.1126/sciadv.abq5575

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