Isoprenaline and salbutamol inhibit pyroptosis and promote mitochondrial biogenesis in arthritic chondrocytes by downregulating β-arrestin and GRK2

Rheumatoid arthritis and osteoarthritis overlap many molecular mechanisms of cartilage destruction. Wear and tear in cartilage is chondrocyte-mediated, where chondrocytes act both as effector and target cells. In current study, role of β2-AR was studied in chondrocytes both in vitro and in vivo. Hig...

Descripción completa

Detalles Bibliográficos
Autores principales: Ajmal, Iqra, Farooq, Muhammad Asad, Abbas, Syed Qamar, Shah, Jaffer, Majid, Muhammad, Jiang, Wenzheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9519065/
https://www.ncbi.nlm.nih.gov/pubmed/36188601
http://dx.doi.org/10.3389/fphar.2022.996321

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9519065/
https://www.ncbi.nlm.nih.gov/pubmed/36188601
http://dx.doi.org/10.3389/fphar.2022.996321

Ejemplares similares