A molecularly engineered, broad-spectrum anti-coronavirus lectin inhibits SARS-CoV-2 and MERS-CoV infection in vivo

“Pan-coronavirus” antivirals targeting conserved viral components can be designed. Here, we show that the rationally engineered H84T-banana lectin (H84T-BanLec), which specifically recognizes high mannose found on viral proteins but seldom on healthy human cells, potently inhibits Middle East respir...

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Detalles Bibliográficos
Autores principales: Chan, Jasper Fuk-Woo, Oh, Yoo Jin, Yuan, Shuofeng, Chu, Hin, Yeung, Man-Lung, Canena, Daniel, Chan, Chris Chung-Sing, Poon, Vincent Kwok-Man, Chan, Chris Chun-Yiu, Zhang, Anna Jinxia, Cai, Jian-Piao, Ye, Zi-Wei, Wen, Lei, Yuen, Terrence Tsz-Tai, Chik, Kenn Ka-Heng, Shuai, Huiping, Wang, Yixin, Hou, Yuxin, Luo, Cuiting, Chan, Wan-Mui, Qin, Zhenzhi, Sit, Ko-Yung, Au, Wing-Kuk, Legendre, Maureen, Zhu, Rong, Hain, Lisa, Seferovic, Hannah, Tampé, Robert, To, Kelvin Kai-Wang, Chan, Kwok-Hung, Thomas, Dafydd Gareth, Klausberger, Miriam, Xu, Cheng, Moon, James J., Stadlmann, Johannes, Penninger, Josef M., Oostenbrink, Chris, Hinterdorfer, Peter, Yuen, Kwok-Yung, Markovitz, David M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9519379/
https://www.ncbi.nlm.nih.gov/pubmed/36195094
http://dx.doi.org/10.1016/j.xcrm.2022.100774

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9519379/
https://www.ncbi.nlm.nih.gov/pubmed/36195094
http://dx.doi.org/10.1016/j.xcrm.2022.100774

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