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Structural interplay between DNA-shape protein recognition and supercoiling: The case of IHF

The integration host factor (IHF) is a prominent example of indirect readout as it imposes one of the strongest bends on relaxed linear DNA. However, the relation between IHF and torsionally constrained DNA, as occurs physiologically, remains unclear. By using atomistic molecular dynamics simulation...

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Detalles Bibliográficos
Autores principales: Watson, George D., Chan, Elliot W., Leake, Mark C., Noy, Agnes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9519438/
https://www.ncbi.nlm.nih.gov/pubmed/36212531
http://dx.doi.org/10.1016/j.csbj.2022.09.020