Rational attenuation of RNA viruses with zinc finger antiviral protein

Attenuation of a virulent virus is a proven approach for generating vaccines but can be unpredictable. For example, synonymous recoding of viral genomes can attenuate replication but sometimes results in pleiotropic effects that confound rational vaccine design. To enable specific, conditional atten...

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Detalles Bibliográficos
Autores principales: Gonçalves-Carneiro, Daniel, Mastrocola, Emily, Lei, Xiao, DaSilva, Justin, Chan, Yoke Fun, Bieniasz, Paul D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9519448/
https://www.ncbi.nlm.nih.gov/pubmed/36075961
http://dx.doi.org/10.1038/s41564-022-01223-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9519448/
https://www.ncbi.nlm.nih.gov/pubmed/36075961
http://dx.doi.org/10.1038/s41564-022-01223-8

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