Non-canonical EphA2 activation underpins PTEN-mediated metastatic migration and poor clinical outcome in prostate cancer

BACKGROUND: The key process of mesenchymal to amoeboid transition (MAT), which enables prostate cancer (PCa) transendothelial migration and subsequent development of metastases in red bone marrow stroma, is driven by phosphorylation of EphA2(S897) by pAkt, which is induced by the omega-6 polyunsatur...

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Detalles Bibliográficos
Autores principales: Sachdeva, Ashwin, Hart, Claire A., Kim, Kyungmin, Tawadros, Thomas, Oliveira, Pedro, Shanks, Jonathan, Brown, Mick, Clarke, Noel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9519535/
https://www.ncbi.nlm.nih.gov/pubmed/35869144
http://dx.doi.org/10.1038/s41416-022-01914-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9519535/
https://www.ncbi.nlm.nih.gov/pubmed/35869144
http://dx.doi.org/10.1038/s41416-022-01914-3

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