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Autoregulation of H(+)/lactate efflux prevents monocarboxylate transport (MCT) inhibitors from reducing glycolytic lactic acid production

BACKGROUND: Pharmacological inhibition of membrane transporters is expected to reduce the flow of solutes, unless flux is restored (i.e., autoregulated) through a compensatory increase in the transmembrane driving force. Drugs acting on monocarboxylate transporters (MCTs) have been developed to disr...

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Detalles Bibliográficos
Autores principales: Blaszczak, Wiktoria, Williams, Hannah, Swietach, Pawel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9519749/
https://www.ncbi.nlm.nih.gov/pubmed/35840734
http://dx.doi.org/10.1038/s41416-022-01910-7