A potential new pathway for heparin treatment of sepsis-induced lung injury: inhibition of pulmonary endothelial cell pyroptosis by blocking hMGB1-LPS-induced caspase-11 activation

Sepsis is a significant cause of mortality in critically ill patients. Acute lung injury (ALI) is a leading cause of death in these patients. Endothelial cells exposed to the bacterial endotoxin lipopolysaccharide (LPS) can progress into pyroptosis, a programmed lysis of cell death triggered by infl...

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Detalles Bibliográficos
Autores principales: Yang, Rui, Zhang, Xiaojuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cellular and Infection Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9519888/
https://www.ncbi.nlm.nih.gov/pubmed/36189354
http://dx.doi.org/10.3389/fcimb.2022.984835

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9519888/
https://www.ncbi.nlm.nih.gov/pubmed/36189354
http://dx.doi.org/10.3389/fcimb.2022.984835

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