The Grb2 splice variant, Grb3-3, is a negative regulator of RAS activation

Activation of RAS is crucial in driving cellular outcomes including proliferation, differentiation, migration and apoptosis via the MAPK pathway. This is initiated on recruitment of Grb2, as part of a Grb2-Sos complex, to an up-regulated receptor tyrosine kinase (RTK), enabling subsequent interactio...

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Detalles Bibliográficos
Autores principales: Seiler, Caroline, Stainthorp, Amy K., Ketchen, Sophie, Jones, Christopher M., Marks, Kate, Quirke, Philip, Ladbury, John E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9519967/
https://www.ncbi.nlm.nih.gov/pubmed/36171279
http://dx.doi.org/10.1038/s42003-022-03985-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9519967/
https://www.ncbi.nlm.nih.gov/pubmed/36171279
http://dx.doi.org/10.1038/s42003-022-03985-7

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