The heme-regulated inhibitor kinase requires dimerization for heme-sensing activity

The heme-regulated inhibitor (HRI) is a heme-sensing kinase that regulates mRNA translation in erythroid cells. In heme deficiency, HRI is activated to phosphorylate eukaryotic initiation factor 2α and halt production of globins, thus avoiding accumulation of heme-free globin chains. HRI is inhibite...

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Detalles Bibliográficos
Autores principales: Ricketts, M. Daniel, Emptage, Ryan P., Blobel, Gerd A., Marmorstein, Ronen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9520036/
https://www.ncbi.nlm.nih.gov/pubmed/36063997
http://dx.doi.org/10.1016/j.jbc.2022.102451

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9520036/
https://www.ncbi.nlm.nih.gov/pubmed/36063997
http://dx.doi.org/10.1016/j.jbc.2022.102451

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