Design, synthesis and biological evaluation of 9-aryl-5H-pyrido[4,3-b]indole derivatives as potential tubulin polymerization inhibitors

A series of new 9-aryl-5H-pyrido[4,3-b]indole derivatives as tubulin polymerization inhibitors were designed, synthesized, and evaluated for antitumor activity. All newly prepared compounds were tested for their anti-proliferative activity in vitro against three different cancer cells (SGC-7901, HeL...

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Detalles Bibliográficos
Autores principales: Shi, Lingyu, Yang, Shanbo, Chang, Jing, Zhang, Yujing, Liu, Wenjing, Zeng, Jun, Meng, Jingsen, Zhang, Renshuai, Wang, Chao, Xing, Dongming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9520531/
https://www.ncbi.nlm.nih.gov/pubmed/36186601
http://dx.doi.org/10.3389/fchem.2022.1004835

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9520531/
https://www.ncbi.nlm.nih.gov/pubmed/36186601
http://dx.doi.org/10.3389/fchem.2022.1004835

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